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KMID : 0359319860260010139
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Korean Journal of Veterinary Research
1986 Volume.26 No. 1 p.139 ~ p.147
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Pathogenesis of Perirenal Edema in Pigs and Rabbits Administered with Oxalate , Nitrate and Calcium
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Abstract
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In order to clarify the pathogenesis of perirenal edema, pigs and rabbits were administered with oxalate and nitrate, with oxalate nitrate and glycolic acid, with oxalate, nitrate and ascorbic acid and with oxalate, nitrate and calcium, respectively.
The results obtained are summarized as follows;
The pigs and rabbits administered with oxalate and nitrate with oxalate. nitrate and glycolic acid and with oxalate, nitrate and ascorbic acid, respectively, were not showed perirenal edema despite of observing the abundant oxalate crystals in the proximal convoluted tubles. But pigs and rabbits administered with oxalate, nitrate and calcium were histopathologically showed perirenal edema similar to those of pigs fed Amaranthus retroflexus. Therefore, author considered that oxalate, nitrate and calcium are main factors to cause perirenal edema. It was regarded that perirenal edema in pigs was caused by the reciprocal reactions of those materials including oxalate, nitrate and calcium which may produce vascular damage, decreased osmotic pressure by hypoproteinemia and increased vascular permeability in kidney, rather than the mechanical obstructions by the oxalate crystals in the proximal convoluted tubule.
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